Article
Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.
Journal of thrombosis and haemostasis : JTH - 1 Oct 2006
Chen D, Weber M, Shiels P G, Dong R, Webster Z, McVey J H, Kemball-Cook G, Tuddenham E G D, Lechler R I, Dorling A
Abstract excerpt
BACKGROUND: Coagulation proteins promote neointimal hyperplasia and vascular remodelling after vessel injury, but the precise mechanisms by which they act in vivo remain undetermined. OBJECTIVES: This study, using an injury model in which the neointima is derived from bone marrow (BM)-derived cells, compared inhibition of tissue factor or thrombin on either BM-derived or existing vascular smooth muscle cells....
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