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Article

Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis

30 Jun 2015

Abstract excerpt

RATIONALE: Wnt/β-catenin signaling has an important role in the angiogenic activity of endothelial cells (ECs). Bach1 is a transcription factor and is expressed in ECs, but whether Bach1 regulates angiogenesis is unknown. OBJECTIVE: This study evaluated the role of Bach1 in angiogenesis and Wnt/β-catenin signaling. METHODS AND RESULTS: Hind-limb ischemia was surgically induced in Bach1(-/-) mice and their...

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Identifiers

PMID: 26123998
DOI: 10.1161/circresaha.115.306829

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