Article
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
Nature communications - 19 Feb 2015
Jäger Roland, Migliorini Gabriele, Henrion Marc, Kandaswamy Radhika, Speedy Helen E, Heindl Andreas, Whiffin Nicola, Carnicer Maria J, Broome Laura, Dryden Nicola, Nagano Takashi, Schoenfelder Stefan, Enge Martin, Yuan Yinyin, Taipale Jussi, Fraser Peter, Fletcher Olivia, Houlston Richard S
Abstract excerpt
Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.