Article
Identifying high-confidence capture Hi-C interactions using CHiCANE.
Nature protocols - 1 Apr 2021
Holgersen Erle M, Gillespie Andrea, Leavy Olivia C, Baxter Joseph S, Zvereva Alisa, Muirhead Gareth, Johnson Nichola, Sipos Orsolya, Dryden Nicola H, Broome Laura R, Chen Yi, Kozin Igor, Dudbridge Frank, Fletcher Olivia, Haider Syed
Abstract excerpt
The ability to identify regulatory interactions that mediate gene expression changes through distal elements, such as risk loci, is transforming our understanding of how genomes are spatially organized and regulated. Capture Hi-C (CHi-C) is a powerful tool to delineate such regulatory interactions. However, primary analysis and downstream interpretation of CHi-C profiles remains challenging and relies on...
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