Article
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.
Genome research - 1 Nov 2014
Dryden Nicola H, Broome Laura R, Dudbridge Frank, Johnson Nichola, Orr Nick, Schoenfelder Stefan, Nagano Takashi, Andrews Simon, Wingett Steven, Kozarewa Iwanka, Assiotis Ioannis, Fenwick Kerry, Maguire Sarah L, Campbell James, Natrajan Rachael, Lambros Maryou, Perrakis Eleni, Ashworth Alan, Fraser Peter, Fletcher Olivia
Abstract excerpt
Genome-wide association studies have identified more than 70 common variants that are associated with breast cancer risk. Most of these variants map to non-protein-coding regions and several map to gene deserts, regions of several hundred kilobases lacking protein-coding genes. We hypothesized that gene deserts harbor long-range regulatory elements that can physically interact with target genes to influence their...
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