Article

Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approaches

2020-12-15

Abstract excerpt

Promoter-focused chromatin conformation techniques directly detect interactions between gene promoters and distal genomic sequences, providing structural information relevant to gene regulation without the excessive non-genic architectural data generated by full scale Hi-C. 3D promoter ‘interactome’ maps are crucial for understanding how epigenomic features like histone modifications and open chromatin, or genetic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00797159-9f70-5d8a-97d6-025b2dfa9c11
DOI: 10.1101/2020.12.15.422932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approachesDOI 10.1101/2020.12.15.422932Read

Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approaches.Semantic proximity Read

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C.Semantic proximity Read

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.Semantic proximity Read

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.Semantic proximity Read

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolutionSemantic proximity Read

Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architectureSemantic proximity Read

Combined promoter-capture Hi-C and Hi-C analysis reveals a fine-tuned regulation of 3D chromatin architecture in colorectal cancerSemantic proximity Read

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.Semantic proximity Read

HUGIn: Hi-C Unifying Genomic Interrogator.Semantic proximity Read

CHiCAGO: Robust Detection of DNA Looping Interactions in Capture Hi-C dataSemantic proximity Read

HUGIn: Hi-C Unifying Genomic InterrogatorSemantic proximity Read

Straightforward protocol for allele-specific chromatin conformation capture.Semantic proximity Read