Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2015

Curtain Michelle, Heffner Caleb S, Maddox Dennis M, Gudis Polyxeni, Donahue Leah Rae, Murray Stephen A

Abstract excerpt

Normal fusion of developing eyelids requires coordination of inductive signals from the eyelid mesenchyme with migration of the periderm cell layer and constriction of the eyelids across the eye. Failure of this process results in an eyelids open at birth (EOB) phenotype in mice. We have identified a novel spontaneous allele of Alx4 that displays EOB, in addition to polydactyly and cranial malformations. Alx4 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Eyelids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

Share to Gene Order

Share to Gene Targeting

Share to Homeodomain Proteins

Share to Mesoderm

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 25673119
DOI: 10.1007/s00335-015-9557-z
PMCID: PMC4482110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice.PMID 25673119Read ↗

Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal DysplasiaSemantic proximity Read ↗

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fateSemantic proximity Read ↗

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential and conserved mediator of epithelial fusion during vertebrate embryogenesisSemantic proximity Read ↗

An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.Semantic proximity Read ↗

Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.Semantic proximity Read ↗

The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid.Semantic proximity Read ↗

Epithelial SOX11 regulates eyelid closure during embryonic eye development.Semantic proximity Read ↗

Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an "eye open at birth" phenotype.Semantic proximity Read ↗

exma: an X-linked insertional mutation that disrupts forebrain and eye development.Semantic proximity Read ↗

Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate.Semantic proximity Read ↗

A comprehensive series of Irx cluster mutants reveals diverse roles in facial cartilage development.Semantic proximity Read ↗

AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.