Article

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential and conserved mediator of epithelial fusion during vertebrate embryogenesis

2018-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure closure (OFC) in the embryonic chick, including strong evidence for roles of apoptosis and epithelial remodelling. We performed...

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Literature Corpus work: 71559e79-54ef-599e-a14c-f1667d134b39
DOI: 10.1101/477729

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