Article
Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an "eye open at birth" phenotype.
Genetics and molecular research : GMR - 26 Aug 2016
Wu L C, Liu C, Jiang M R, Jiang Y M, Wang Q H, Lu Z Y, Wang S J, Yang W L, Shao Y X
Abstract excerpt
Development of the eyelid requires coordination of the cellular processes involved in proliferation, cell size alteration, migration, and cell death. C57BL/6J-corneal opacity (B6-Co) mice are mutant mice generated by the administration of N-ethyl-N-nitrosourea (100 mg/kg). They exhibit the eyelids open at birth phenotype, abnormal round cell shape from tightened F-actin bundles in leading edge keratinocytes at...
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