Article
exma: an X-linked insertional mutation that disrupts forebrain and eye development.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2002
Cunningham David, Xiao Qiang, Chatterjee Aurobindo, Sulik Kathleen, Juriloff Diana, Elder Frederick, Harrison Wilbur, Schuster Gabriele, Overbeek Paul A, Herman Gail E
Abstract excerpt
Formation of the neural tube plays a primary role in establishing the body plan of the vertebrate embryo. Here we describe the phenotype and physical mapping of a highly penetrant X-linked male-lethal murine mutation, exma (exencephaly, microphthalmia/anophthalmia), that specifically disrupts development of the rostral neural tube and eye. The mutation arose from the random insertion of a transgene into the mouse...
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