AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle.

Abstract excerpt

AP-2 transcription factors are a family of retinoic acid-responsive genes, which are involved in complex morphogenetic processes. In the current study, we determine the requirement for AP-2alpha in early morphogenesis of the eye by examining the nature of the ocular defects in AP-2alpha null and chimeric mice. AP-2alpha null embryos exhibited ocular phenotypes ranging from a complete lack of eyes (anophthalmia)...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA-Binding Proteins
• Share to Gene Expression Regulation, Developmental