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Article

Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2015

Jeffery Jessie, Neyt Christine, Moore Wade, Paterson Scott, Bower Neil I, Chenevix-Trench Georgia, Verkade Heather, Hogan Benjamin M, Khanna Kum Kum

Abstract excerpt

CEP55 was initially described as a centrosome- and midbody-associated protein and a key mediator of cytokinesis. More recently, it has been implicated in PI3K/AKT pathway activation via an interaction with the catalytic subunit of PI3K. However, its role in embryonic development is unknown. Here we describe a cep55 nonsense mutant zebrafish with which we can study the in vivo physiologic role of Cep55. Homozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique

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Source

Identifiers

PMID: 25667221
DOI: 10.1096/fj.14-265090

Genes

AKT1
CEP55

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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