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Article

PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways.

Genes & development - 1 May 2014

Fantauzzo Katherine A, Soriano Philippe

Abstract excerpt

Previous studies have identified phosphatidylinositol 3-kinase (PI3K) as the main downstream effector of PDGFRα signaling during murine skeletal development. Autophosphorylation mutant knock-in embryos in which PDGFRα is unable to bind PI3K (Pdgfra(PI3K/PI3K)) exhibit skeletal defects affecting the palatal shelves, shoulder girdle, vertebrae, and sternum. To identify proteins phosphorylated by Akt downstream from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

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Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 24788519
DOI: 10.1101/gad.238709.114
PMCID: PMC4018488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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