Article

Cep55 overexpression promotes genomic instability and tumorigenesis in mice

2019-09-24

Abstract excerpt

High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal role in vivo tumorigenesis remains elusive. Here, using a ubiquitously overexpressing transgenic mouse model, we show that Cep55 overexpression causes spontaneou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a8b5c8b-2311-50e3-a811-6974cb699e28
DOI: 10.1101/780775

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cep55 overexpression promotes genomic instability and tumorigenesis in miceDOI 10.1101/780775Read

Cep55 overexpression promotes genomic instability and tumorigenesis in mice.Semantic proximity Read

Genetic Ablation and Multi-Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer ModelsSemantic proximity Read

Genetic Ablation and Multi-Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer ModelsSemantic proximity Read

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancerSemantic proximity Read

Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish.Semantic proximity Read

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesisSemantic proximity Read

Plk1 overexpression induces chromosomal instability and suppresses tumor developmentSemantic proximity Read

CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cellsSemantic proximity Read

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.Semantic proximity Read

CEP55 as a Promising Immune Intervention Marker to Regulate Tumor Progression: A Pan-Cancer Analysis with Experimental VerificationSemantic proximity Read

Centrosomal Protein 55 (CEP55) Drives Immune Exclusion and Resistance to Immune Checkpoint Inhibitors in Colorectal CancerSemantic proximity Read

Cep55 overexpression causes male‐specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signalingSemantic proximity Read