Article
Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Communications biology - 21 Oct 2020
Sinha Debottam, Nag Purba, Nanayakkara Devathri, Duijf Pascal H G, Burgess Andrew, Raninga Prahlad, Smits Veronique A J, Bain Amanda L, Subramanian Goutham, Wall Meaghan, Finnie John W, Kalimutho Murugan, Khanna Kum Kum
Abstract excerpt
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal role in vivo tumorigenesis remains elusive. Here, using a ubiquitously overexpressing transgenic mouse model, we show that Cep55 overexpression causes spontaneous...
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