Article

Genetic Ablation and Multi-Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

2025-10-30

Abstract excerpt

<h4>Background</h4> CEP55 is a centrosomal protein with emerging oncogenic roles. It is overexpressed in many cancers, where it drives genomic instability, phenocopies PTEN loss and hyperactivates the PI3K/AKT pathway, thereby promoting aggressive and therapy-resistant tumors. <h4>Methods</h4> We developed an inducible Cep55 knockout (KO) mouse model as well as generated primary, immortalized (SV40), and transfo...

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Literature Corpus work: a4949d83-87e0-5892-9363-d8b6f4141c48
DOI: 10.1101/2025.10.28.685219

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