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Article

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.

PLoS genetics - 1 Oct 2021

Rashidieh Behnam, Shohayeb Belal, Bain Amanda Louise, Fortuna Patrick R J, Sinha Debottam, Burgess Andrew, Mills Richard, Adams Rachael C, Lopez J Alejandro, Blumbergs Peter, Finnie John, Kalimutho Murugan, Piper Michael, Hudson James Edward, Ng Dominic C H, Khanna Kum Kum

Abstract excerpt

Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a critical role in regulation of embryonic development. CEP55 has previously been studied as a crucial regulator of cytokinesis, predominantly in transformed cells, and its dysregulation is linked to carcinogenesis. However, its molecular functions during embryonic...

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Identifiers

PMID: 34710087
DOI: 10.1371/journal.pgen.1009334
PMCID: PMC8577787

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