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Article

Cep55 overexpression causes male‐specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

17 Apr 2018

Abstract excerpt

ABSTRACT Spermatogenesis is a dynamic process involving self‐renewal and differentiation of spermatogonial stem cells, meiosis, and ultimately, the differentiation of haploid spermatids into sperm. Centrosomal protein 55 kDa (CEP55) is necessary for somatic cell abscission during cytokinesis. It facilitates equal segregation of cytoplasmic contents between daughter cells by recruiting endosomal sorting complex...

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PMID: 29683733
DOI: 10.1096/fj.201701096rr

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