Article
Genetic Ablation and Multi-Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models
2025-11-28
Abstract excerpt
<title>Abstract</title> <p> Background – CEP55 is a centrosomal protein with emerging oncogenic roles. It is overexpressed in many cancers, where it drives genomic instability, phenocopies PTEN loss and hyperactivates the PI3K/AKT pathway, thereby promoting aggressive and therapy-resistant tumors. Methods – We developed an inducible Cep55 knockout (KO) mouse model as well as generated primary, immortalized (SV40...
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Identifiers and source
- Literature Corpus work
- 27c9f0d4-6466-5a3b-8a44-5220823ae59e
- DOI
- 10.21203/rs.3.rs-8060108/v1