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<i>Spata6</i> is required for normal assembly of the sperm connecting piece and tight head–tail conjunction

20 Jan 2015

Abstract excerpt

"Pinhead sperm," or "acephalic sperm," a type of human teratozoospermia, refers to the condition in which ejaculate contains mostly sperm flagella without heads. Family clustering and homogeneity of this syndrome suggests a genetic basis, but the causative genes remain largely unknown. Here we report that Spata6, an evolutionarily conserved testis-specific gene, encodes a protein required for formation of the...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 25605924
DOI: 10.1073/pnas.1424648112

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