Article

Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure and nuclear integrity

2022-08-03

Abstract excerpt

The development and function of male gametes is critically dependent on a dynamic microtubule network, yet how this is regulated remains poorly understood. We have recently shown that microtubule severing, via the action of the meiotic AAA ATPase protein clade, plays a critical role in this process. Here, we sought to elucidate the roles of spastin, an as yet unexplored member of this clade in spermatogenesis. Usi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89a8ff33-1844-5cfd-812c-072f6dbd3a5c
DOI: 10.1101/2022.08.01.502419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure and nuclear integrityDOI 10.1101/2022.08.01.502419Read

Male mammalian meiosis and spermiogenesis is critically dependent on the shared functions of the katanins KATNA1 and KATNAL1Semantic proximity Read

The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertilitySemantic proximity Read

SPAG17 Is Required for Male Germ Cell Differentiation and FertilitySemantic proximity Read

<i>Spata6</i> is required for normal assembly of the sperm connecting piece and tight head–tail conjunctionSemantic proximity Read

The AAA ATPase spastin links microtubule severing to membrane modelling.Semantic proximity Read

BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assemblySemantic proximity Read

KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.Semantic proximity Read

Spastin and microtubules: Functions in health and diseaseSemantic proximity Read

Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.Semantic proximity Read

Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice†Semantic proximity Read

CAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesisSemantic proximity Read

Nucleoporin NUP210L and BAF-paralogue BAF-L together ensure microtubule organization and nuclear integrity in spermatidsSemantic proximity Read