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BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly

7 Mar 2024

Abstract excerpt

Teratozoospermia is a significant cause of male infertility, but the pathogenic mechanism of acephalic spermatozoa syndrome (ASS), one of the most severe teratozoospermia, remains elusive. We previously reported Spermatogenesis Associated 6 (SPATA6) as the component of the sperm head-tail coupling apparatus (HTCA) required for normal assembly of the sperm head-tail conjunction, but the underlying molecular...

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PMID: 38454159
DOI: 10.1038/s44319-024-00112-x

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