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Article

Identification of nonfunctional SPATA20 causing acephalic spermatozoa syndrome in humans.

Clinical genetics - 1 Mar 2023

Wang Xiang, Jiang Chuan, Dai Siyu, Shen Gan, Yang Yihong, Shen Ying

Abstract excerpt

Acephalic spermatozoa syndrome (ASS) is a rare and severe type of teratozoospermia characterized by the predominance of headless spermatozoa in the ejaculate. However, knowledge about the causative genes associated with ASS in humans is limited. Loss-of-function of SPATA20 has been suggested to result in the separation of the sperm head and flagellum in mice, whereas there have been no cases reporting SPATA20...

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Identifiers

PMID: 36415156
DOI: 10.1111/cge.14268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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