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Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct

9 Aug 2025

Abstract excerpt

In male reproduction, spermatogenesis and sperm maturation are critical for the production of normal sperm and offspring, yet the underlying molecular mechanisms remain largely elusive. Tex38 is a testis-enriched gene, and its deficiency results in oligoasthenoteratospermia (OAT) with aberrant epididymis, leading to male infertility in mice. Tex38 knockout (KO) sperm primarily exhibited neck bending deformities...

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PMID: 40783453
DOI: 10.1038/s42003-025-08644-1

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