Article
Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.
Asian journal of andrology - 1 Mar 2025
Liu Tao, Rahim Fazal, Yang Meng-Lei, Uddin Meftah, Ye Jing-Wei, Ali Imtiaz, Raza Yousaf, Mansoor Abu, Shoaib Muhammad, Hussain Mujahid, Khan Ihsan, Shah Basit, Khan Asad, Nisar Ahmad, Ma Hui, Xu Bo, Shah Wasim, Shi Qing-Hua
Abstract excerpt
ABSTRACT: Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella (MMAF). Distinct projections encircling the central microtubules of the spermatozoal axoneme play pivotal roles in flagellar bending and spermatozoal movement. Mammalian sperm-associated antigen 17 ( SPAG17 ) encodes a conserved axonemal protein of cilia and flagella, forming part of...
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