Article
The +190 G/A (rs1799864) polymorphism in the C-C chemokine receptor 2 (CCR2) gene is associated with susceptibility to multiple sclerosis in HLA-DRB1*15:01-negative individuals.
Journal of the neurological sciences - 15 Feb 2015
Javor Juraj, Párnická Zuzana, Michalik Jozef, Čopíková-Cudráková Daniela, Shawkatová Ivana, Ďurmanová Vladimíra, Gmitterová Karin, Klímová Eleonóra, Bucová Mária, Buc Milan
Abstract excerpt
C-C chemokine receptor 2 (CCR2) is one of the key players involved in the transmigration of mononuclear cells into the central nervous system (CNS) and subsequent development of multiple sclerosis (MS). The aim of the current study was to analyse the association of CCR2 +190 G/A (rs1799864) polymorphism with susceptibility to MS and its influence on the age at onset, severity and neurological disability in MS....
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