Analysis of Cdx2 VDR gene polymorphism rs11568820 in association with multiple sclerosis in Slovaks.

doi:10.1080/01616412.2023.2247195

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Article

Analysis of Cdx2 VDR gene polymorphism rs11568820 in association with multiple sclerosis in Slovaks.

Neurological research - 1 Oct 2023

Čierny Daniel, Dobrota Dušan, Kantorová Ema, Malicherová Bibiana, Škereňová Mária, Javor Juraj, Kurča Egon, Lehotský Ján

Abstract excerpt

Vitamin D deficiency is involved in the pathogenesis of multiple sclerosis (MS), a severe autoimmune demyelinating disease of the central nervous system. The gene polymorphism Cdx-2 (rs11568820, G/A) seriously influences the trancriptional activity of the vitamin D receptor (VDR) that binds the vitamin D responsive elements of target genes including HLA-DRB1*15. The aim of the present study in Slovaks was to...

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PMID: 37581270
DOI: 10.1080/01616412.2023.2247195

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