The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR.

doi:10.1016/j.cca.2009.05.004

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Article

The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR.

Clinica chimica acta; international journal of clinical chemistry - 1 Aug 2009

Zivković Maja, Stanković Aleksandra, Dincić Evica, Popović Milan, Popović Smiljana, Raicević Ranko, Alavantić Dragan

Abstract excerpt

BACKGROUND: Recently a high-resolution HLA and SNP map was defined and the analysis provided informative tag SNPs that capture much of the common variation in the MHC region. This concept enables detection of smaller number of SNPs, making it "surrogate" markers for haplotype associated with certain disease. The SNP rs3135388 was proposed as a tagging SNP for DRB1*1501/DQB10602 alleles, associated with MS. The...

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PMID: 19433080
DOI: 10.1016/j.cca.2009.05.004

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