Article
The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females.
Arquivos de neuro-psiquiatria - 1 Apr 2015
Paradela Eduardo R, Alves-Leon Soniza V, Figueiredo André L S, Pereira Valéria C S R, Malfetano Fabíola, Mansur Letícia F, Scherpenhuijzen Simone, Agostinho Luciana A, Rocha Catielly F, Rueda-Lopes Fernanda, Gasparetto Emerson, Paiva Carmen L A
Abstract excerpt
The objective of this study was to investigate the association between the HLA alleles at the DQA1, DQB1 and DRB1 loci, the CIITA genetic polymorphisms -168A/G and +1614G/C, and susceptibility to multiple sclerosis (MS) in a sample from Rio de Janeiro State, Brazil. Furthermore, we wished to determine whether any of these associations might be more significant in women compared with men. DNA samples from 52...
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