Article
Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.
Genes and immunity - 1 Mar 2010
Ockinger J, Stridh P, Beyeen A D, Lundmark F, Seddighzadeh M, Oturai A, Sørensen P S, Lorentzen A R, Celius E G, Leppä V, Koivisto K, Tienari P J, Alfredsson L, Padyukov L, Hillert J, Kockum I, Jagodic M, Olsson T
Abstract excerpt
Multiple sclerosis (MS) is a complex disorder of the central nervous system, causing inflammation, demyelination and axonal damage. A limited number of genetic risk factors for MS have been identified, but the etiology of the disease remains largely unknown. For the identification of genes regulating neuroinflammation we used a rat model of MS, myelin oligodendrocyte glycoprotein (MOG)-induced experimental...
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