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Article

Mutational spectrum of adult T-ALL.

Oncotarget - 20 Feb 2015

Neumann Martin, Vosberg Sebastian, Schlee Cornelia, Heesch Sandra, Schwartz Stefan, Gökbuget Nicola, Hoelzer Dieter, Graf Alexander, Krebs Stefan, Bartram Isabelle, Blum Helmut, Brüggemann Monika, Hecht Jochen, Bohlander Stefan K, Greif Philipp A, Baldus Claudia D

Abstract excerpt

Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic leukemia (T-ALL) patients. We provide a comprehensive study on mutations to enhance the understanding of therapeutic targets and studied 81 adult T-ALL patients. NOTCH1 exhibitedthe highest mutation rate (53%). Mutation frequencies of FBXW7 (10%), WT1 (10%), JAK3 (12%), PHF6 (11%), and BCL11B (10%) were in line with...

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Source

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Identifiers

PMID: 25595890
DOI: 10.18632/oncotarget.2218
PMCID: PMC4413615

Genes

DNM2
FAT1
HERC1
JAK3
NOTCH1
NOTCH2
PHF6
RELN
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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