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Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia

25 Aug 2021

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted therapy and detailed understanding of the genetic alterations driving leukemogenesis and therapeutic response may dramatically improve treatment outcomes, with cure rates now exceeding 90% in children. However, ALL still represents a leading cause of cancer-related death in the young, and the outcome for older adolescents and...

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PMID: 34501239
DOI: 10.3390/jcm10173792

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