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Targeted sequencing to identify genetic alterations and prognostic markers in pediatric T-cell acute lymphoblastic leukemia.

Scientific reports - 12 Jan 2021

Chang Ya-Hsuan, Yu Chih-Hsiang, Jou Shiann-Tarng, Lin Chien-Yu, Lin Kai-Hsin, Lu Meng-Yao, Wu Kang-Hsi, Chang Hsiu-Hao, Lin Dong-Tsamn, Lin Shu-Wha, Chen Hsuan-Yu, Yang Yung-Li

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is caused by the accumulation of multiple genetic alterations. To determine the frequency of common genetic mutations and possible prognostic markers in childhood T-ALL, we performed targeted sequencing of 67 genes across 64 cases treated according to Taiwan Pediatric Oncology Group protocols between January 2002 and December 2015. Together, 302 variants were identified...

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PMID: 33436855
DOI: 10.1038/s41598-020-80613-6
PMCID: PMC7804301

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