Article
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
Genes, chromosomes & cancer - 1 Apr 2013
Grossmann Vera, Haferlach Claudia, Weissmann Sandra, Roller Andreas, Schindela Sonja, Poetzinger Franziska, Stadler Kathrin, Bellos Frauke, Kern Wolfgang, Haferlach Torsten, Schnittger Susanne, Kohlmann Alexander
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and heterogeneous disease. The diagnosis is predominantly based on immunophenotyping. In addition to known cytogenetic abnormalities molecular mutations were recently identified. Here, 90 adult T-ALL cases were investigated for mutations in NOTCH1, FBXW7, PHF6, CDKN2A, DNMT3A, FLT3, PTEN, and RUNX1 using 454 next-generation amplicon sequencing and...
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