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Article

On the stability of parainfluenza virus 5 F proteins.

Journal of virology - 1 Mar 2015

Poor Taylor A, Song Albert S, Welch Brett D, Kors Christopher A, Jardetzky Theodore S, Lamb Robert A

Abstract excerpt

The crystal structure of the F protein (prefusion form) of the paramyxovirus parainfluenza virus 5 (PIV5) WR isolate was determined. We investigated the basis by which point mutations affect fusion in PIV5 isolates W3A and WR, which differ by two residues in the F ectodomain. The P22 stabilizing site acts through a local conformational change and a hydrophobic pocket interaction, whereas the S443 destabilizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25589638
DOI: 10.1128/JVI.03221-14
PMCID: PMC4337539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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