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Article

How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody.

Nature communications - 12 Oct 2024

Marcink Tara C, Zipursky Gillian, Sobolik Elizabeth B, Golub Kate, Herman Emily, Stearns Kyle, Greninger Alexander L, Porotto Matteo, Moscona Anne

Abstract excerpt

Paramyxoviruses including measles, Nipah, and parainfluenza viruses are public health threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading cause of illness in pediatric, older, and immunocompromised populations. There are no approved vaccines or therapeutics for HPIV3. Neutralizing monoclonal antibodies (mAbs) that target viral fusion are a potential strategy for mitigating...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39396053
DOI: 10.1038/s41467-024-53082-y
PMCID: PMC11470942

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