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Article

Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2016

Song Albert S, Poor Taylor A, Abriata Luciano A, Jardetzky Theodore S, Dal Peraro Matteo, Lamb Robert A

Abstract excerpt

Parainfluenza virus 5 (PIV5) is an enveloped, single-stranded, negative-sense RNA virus of the Paramyxoviridae family. PIV5 fusion and entry are mediated by the coordinated action of the receptor-binding protein, hemagglutinin-neuraminidase (HN), and the fusion protein (F). Upon triggering by HN, F undergoes an irreversible ATP- and pH-independent conformational change, going down an energy gradient from a...

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Identifiers

PMID: 27335462
DOI: 10.1073/pnas.1608349113
PMCID: PMC4941503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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