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Article

Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion.

Journal of molecular biology - 13 Feb 2009

Bissonnette Mei Lin Z, Donald Jason E, DeGrado William F, Jardetzky Theodore S, Lamb Robert A

Abstract excerpt

To enter cells, enveloped viruses use fusion-mediating glycoproteins to facilitate the merger of the viral and host cell membranes. These glycoproteins undergo large-scale irreversible refolding during membrane fusion. The paramyxovirus parainfluenza virus 5 mediates membrane merger through its fusion protein (F). The transmembrane (TM) domains of viral fusion proteins are typically required for fusion. The TM...

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Identifiers

PMID: 19121325
DOI: 10.1016/j.jmb.2008.12.029
PMCID: PMC2750892

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