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Article

Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Yin Hsien-Sheng, Paterson Reay G, Wen Xiaolin, Lamb Robert A, Jardetzky Theodore S

Abstract excerpt

Class I viral fusion proteins share common mechanistic and structural features but little sequence similarity. Structural insights into the protein conformational changes associated with membrane fusion are based largely on studies of the influenza virus hemagglutinin in pre- and postfusion conformations. Here, we present the crystal structure of the secreted, uncleaved ectodomain of the paramyxovirus, human...

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Identifiers

PMID: 15964978
DOI: 10.1073/pnas.0503989102
PMCID: PMC1151655

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Source receipt: pubmed, retrieved 7 Sept 2026.

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