Article
A single amino acid residue change in the P protein of parainfluenza virus 5 elevates viral gene expression.
Journal of virology - 1 Sept 2008
Timani Khalid A, Sun Dengyun, Sun Minghao, Keim Celia, Lin Yuan, Schmitt Phuong Tieu, Schmitt Anthony P, He Biao
Abstract excerpt
Parainfluenza virus 5 (PIV5) is a prototypical paramyxovirus. The V/P gene of PIV5 encodes two mRNA species through a process of pseudotemplated insertion of two G residues at a specific site during transcription, resulting in two viral proteins, V and P, whose N termini of 164 amino acid residues are identical. Previously it was reported that mutating six amino acid residues within this identical region results...
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