Article
Fusion protein of the paramyxovirus SV5: destabilizing and stabilizing mutants of fusion activation.
Virology - 25 Apr 2000
Paterson R G, Russell C J, Lamb R A
Abstract excerpt
The fusion (F) protein of the paramyxovirus SV5 strain W3A causes syncytium formation without coexpression of the SV5 hemagglutinin-neuraminidase (HN) glycoprotein, whereas the F protein of the SV5 strain WR requires coexpression of HN for fusion activity. SV5 strains W3A and WR differ by three amino acid residues at positions 22, 443, and 516. The W3A F protein residues P22, S443, and V516 were changed to amino...
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