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Article

Functional and antigenic constraints on the Nipah virus fusion protein.

Proceedings of the National Academy of Sciences of the United States of America - 10 Feb 2026

Larsen Brendan B, Harari Sheri, Gen Risako, Stewart Cameron, Veesler David, Bloom Jesse D

Abstract excerpt

Nipah virus is a highly pathogenic virus in the family Paramyxoviridae that utilizes two distinct surface glycoproteins to infect cells. The receptor-binding protein (RBP) binds host receptors whereas the fusion protein (F) merges viral and host membranes. Here, we use nonreplicative pseudoviruses to safely measure the effects of all F single amino acid residue mutations on its cell entry function and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41650235
DOI: 10.1073/pnas.2529505123
PMCID: PMC12885220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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