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Article

KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2015

Hartikainen Jaana M, Tengström Maria, Winqvist Robert, Jukkola-Vuorinen Arja, Pylkäs Katri, Kosma Veli-Matti, Soini Ylermi, Mannermaa Arto

Abstract excerpt

PURPOSE: Defective oxidative stress response may increase cancer susceptibility. In tumors, these rescue mechanisms may cause chemo- and radioresistance impacting patient outcome. We previously showed that genetic variation in the nuclear factor erythroid 2-related factor 2 (NFE2L2) is associated with breast cancer risk and prognosis. Here we further studied this pathway by investigating Kelch-like ECH-associated...

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Source

Identifiers

PMID: 25589623
DOI: 10.1158/1078-0432.CCR-14-1887

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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