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Article

Oxidative Stress-Related KEAP1 and NRF2 Genes Contributed to the Risk of Epithelial Ovarian Cancer.

Biochemical genetics - 1 Feb 2026

Tong Xiaoqian, Zhu Xiaoli, Wang Xila, Xu Yanlin, Huang Pei, Zhou Leiqing, Ji Yanxiang, Wu Lifang

Abstract excerpt

The NRF2/KEAP1 signaling pathway, crucial for cellular defense against oxidative stress, may influence epithelial ovarian cancer (EOC) risk. This study investigates the association between KEAP1 gene polymorphisms and EOC risk in Han Chinese individuals, while exploring correlations between these genetic variants and serum levels of KEAP1 and NRF2 proteins. We conducted a case-control study involving 1962 EOC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39945964
DOI: 10.1007/s10528-025-11044-z

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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