Article

Aberrant epigenetic and transcriptional events associated with breast cancer risk

2021-09-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Genome-wide association studies have identified several breast cancer susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we investigated cancer-related molecular changes detected in tissues from women at high risk for breast cancer prior to disease manifestation. Disease-free breast tissue cores donated by healthy women (N=146, median age=3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 724c4c5f-5bc9-5d0b-900a-3d1eb7ba0f1b
DOI: 10.1101/2021.09.14.460320

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant epigenetic and transcriptional events associated with breast cancer riskDOI 10.1101/2021.09.14.460320Read

DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controlsSemantic proximity Read

DNA methylation differences at regulatory elements are associated with the cancer risk factor age in normal breast tissueSemantic proximity Read

Interplay Between Genetic and Epigenetic Changes in Breast Cancer Subtypes.Semantic proximity Read

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast CancerSemantic proximity Read

Genomic and transcriptional aberrations linked to breast cancer pathophysiologiesSemantic proximity Read

Prognostic Analysis of Patients with Breast Cancer Based on Tumor Mutational Burden, DNA Damage Repair Genes, and Immune InfiltrationSemantic proximity Read

Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.Semantic proximity Read

Prognostic analysis of patients with breast cancer based on tumor mutational burden and DNA damage repair genesSemantic proximity Read

Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse OutcomesSemantic proximity Read

Inherited and acquired alterations in development of breast cancerSemantic proximity Read

Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics.Semantic proximity Read

Multi-omics analyses unravel DNA damage repair-related clusters in breast cancer with experimental validationSemantic proximity Read