Article
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Redox biology - 1 Feb 2024
Deen Ashik Jawahar, Adinolfi Simone, Härkönen Jouni, Patinen Tommi, Liu Xiaonan, Laitinen Tuomo, Takabe Piia, Kainulainen Kirsi, Pasonen-Seppänen Sanna, Gawriyski Lisa M, Arasu Uma Thanigai, Selvarajan Ilakya, Mäkinen Petri, Laitinen Hanna, Kansanen Emilia, Kaikkonen Minna U, Poso Antti, Varjosalo Markku, Levonen Anna-Liisa
Abstract excerpt
The Kelch-like ECH-associated protein 1 (KEAP1) - Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 is frequently constitutively active in many cancers, rendering the cells resistant to chemo- and radiotherapy. Loss-of-function (LOF) mutations in the repressor protein KEAP1 are common in...
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