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Article

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

15 Jun 2011

Abstract excerpt

Resistance to platinum-based chemotherapy develops in the majority of patients with epithelial ovarian cancer (EOC). Platinum compounds form electrophilic intermediates that mediate DNA cross-linking and induce double-strand DNA breaks. Because the cellular response to electrophilic xenobiotics is partly mediated by Keap1-Nrf2 pathway, we evaluated the presence of Kelch-like ECH-associated protein 1 (Keap1)...

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PMID: 21676886
DOI: 10.1158/0008-5472.can-10-4668

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