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Article

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.

Trends in biochemical sciences - 1 Apr 2009

Hayes John D, McMahon Michael

Abstract excerpt

Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in response to redox stress. NRF2 is negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1). Tumours from approximately 15% of patients with lung cancer harbour somatic mutations in KEAP1 that prevent effective NRF2...

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Source

Identifiers

PMID: 19321346
DOI: 10.1016/j.tibs.2008.12.008

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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