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A catalogue of somatic NRF2 gain-of-function mutations in cancer

21 Aug 2018

Abstract excerpt

Identification and characterization of somatic mutations in cancer have important prognostication and treatment implications. Genes encoding the Nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor and its negative regulator, Kelch-like ECH-associated protein 1 (KEAP1), are frequently mutated in cancer. These mutations drive constitutive NRF2 activation and correlate with poor prognosis....

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PMID: 30150714
DOI: 10.1038/s41598-018-31281-0

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