Article
A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow.
Blood - 12 Mar 2015
Mei Henrik E, Wirries Ina, Frölich Daniela, Brisslert Mikael, Giesecke Claudia, Grün Joachim R, Alexander Tobias, Schmidt Stefanie, Luda Katarzyna, Kühl Anja A, Engelmann Robby, Dürr Michael, Scheel Tobias, Bokarewa Maria, Perka Carsten, Radbruch Andreas, Dörner Thomas
Abstract excerpt
Specific serum antibodies mediating humoral immunity and autoimmunity are provided by mature plasma cells (PC) residing in the bone marrow (BM), yet their dynamics and composition are largely unclear. We here characterize distinct subsets of human PC differing by CD19 expression. Unlike CD19(+) PC, CD19(-) PC were restricted to BM, expressed predominantly IgG, and they carried a prosurvival, distinctly mature...
Topics
- Antigens, CD19
- Antilymphocyte Serum
- Bone Marrow Cells
- Boronic Acids
- Bortezomib
- Cell Differentiation
- Cell Survival
- Diphtheria-Tetanus Vaccine
- Humans
- Immunity, Humoral